1/8/2023 0 Comments Vitiligo universalis![]() Another clinical form is inflammatory vitiligo, with a raised red border similar to pityriasis versicolor. It can sometimes show a trichrome coloration (band of tan color between the white macule and healthy skin) or quadrichrome coloration (perifollicular or marginal macular hyperpigmentation in cases of repigmenting vitiligo). Clinically, vitiligo presents as round or oval white, hypopigmented macules with regular borders. The worldwide prevalence is estimated to be 0.5% 2 and the incidence is approximately 1% to 2% in the general population. 1 The main burden of the disease is its effect on the psychological state of the patient. The condition is usually acquired, although congenital and familial cases have been reported. Vitiligo is a disorder characterized by well-delimited white, hypopigmented macules with no detectable melanocytes. El estudio de los factores asociados a los mecanismos de inmunopatogenicidad antitumoral, así como a la autoinmunidad es, en potencia, una vía alternativa para el diagnóstico y tratamiento de patologías como el vitíligo y el melanoma maligno. A través de diversos estudios en humanos y modelos animales se ha observado que, tanto la inmunidad humoral como la celular tienen un papel inmunorregulador en la citotoxicidad contra el tumor o contra las células melanocíticas. Tanto en los pacientes con vitíligo como con melanoma se ha observado una respuesta inmune contra antígenos de las células melanocíticas, ya sea para la destrucción de los melanocitos normales como de las células tumorales. La leucodermia es un fenómeno de despigmentación cutánea, que ocasionalmente se puede asociar a melanoma. El melanoma es una neoplasia maligna derivada de los melanocitos, que es letal si no se trata oportunamente. ![]() Se caracteriza por la pérdida de melanocitos y se ha hipotetizado que un mecanismo autoinmune podría estar estrechamente relacionado con este fenómeno de despigmentación. The study of factors associated with anti-tumor immunopathogenic mechanisms -autoimmunity for example-may provide us with tools for the diagnosis and treatment of diseases such as vitiligo and malignant melanoma.Įl vitíligo es una patología cutánea que se manifiesta en forma de manchas hipocrómicas y acrómicas. Studies in animal models and humans have shown that humoral and cell-mediated immune responses are involved in modulating cytotoxic activity against tumor cells and normal melanocytes. An immune response against melanocyte antigens leading to destruction of either melanoma cells or melanocytes has been observed in both vitiligo and melanoma. Leukoderma, a condition characterized by depigmentation of the skin, is sometimes associated with malignant melanoma. Melanoma is a malignancy that develops in melanocytes if not detected and treated early, it is often deadly. Melanocyte loss is a feature of the disease, and it has been hypothesized that an autoimmune mechanism could be responsible for the depigmentation. ![]() Vitiligo is a skin condition characterized by white, hypopigmented macules.
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